Southampton will be without suspended midfielder Pierre-Emile Hojbjerg for the Carabao Cup second-round tie at Brighton.
The Denmark international serves a one-match ban after being sent off for two yellow cards against Leicester on Saturday.
Saints boss Mark Hughes intends to make changes at the Amex Stadium which may mean a debut for goalkeeper Angus Gunn. Defenders Matt Targett and Jan Bednarek, captain Steven Davis and striker Manolo Gabiaddini could make their first starts of the season.
Provisional squad: McCarthy, Gunn, Forster, Soares, Stephens, Yoshida, Vestergaard, Hoedt, Bertrand, Bednarek, McQueen, Targett, Davis, Romeu, Lemina, Ward-Prowse, Armstrong, Elyounoussi, Redmond, Gallagher, Long, Gabbiadini, Austin.
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