Paul Pogba will start against CSKA Moscow on Tuesday after Manchester United decided not to appeal against his red card at Arsenal.
The France midfielder was dismissed at the Emirates Stadium on Saturday and is set to serve a three-game domestic ban.
It is understood United have not contested the dismissal and that the FA will not impose an additional punishment after Pogba appeared to respond to the red card with a sarcastic clap.
That means the midfielder will take the field in United’s final Champions League group game – where the possibility of equalling a club record of 40 successive home games without defeat is arguably the most important prize at stake.
The Red Devils officially need a point to assure top spot and qualification but only an extreme contrivance of results and goal difference would see them miss out on the last 16.
“He’s happy to play tomorrow. It’s the next match, the match that matters. He plays tomorrow,” said manager Jose Mourinho.
“He’s very happy to play and try to keep his momentum because since he was back from his injury he’s been phenomenal.”
Zlatan Ibrahimovic, on the other hand, is being treated with kid gloves ahead of Sunday’s top-of-the-table clash against Manchester City.
The Swede has made four substitute appearances since his earlier-than-expected return from knee ligament damage, but was absent from the squad when United defeated Arsenal on Saturday.
Mourinho confirmed it was a conditioning issue rather than a fresh injury which kept the striker out at the Emirates and he will give Ibrahimovic every chance of being ready to face Pep Guardiola and company.
“Zlatan is not injured. He will be out again for tomorrow, but I believe he will be back to normal work after CSKA,” said Mourinho.
“Zlatan needs some time of very hard work on the muscular area that supports the knee that had the problem. When the time for that hard work comes, the fatigue comes. To work really hard for a certain period of time, he cannot play these days.
“He is on his cycle of work divided between the gym and the pitch.”
The CSKA match will also see Luke Shaw return to the matchday squad.
The England international has been restricted to just 48 minutes this season amid rumours he is on his way out of Old Trafford, but could make a rare European outing this week.
There will definitely be a change in goal, with David de Gea rested in favour of Sergio Romero and Joel Pereira on the bench.
De Gea is turning in another superb season for United but Mourinho offered a playful response when asked if he had seen a better goalkeeper this year.
“Yes. Romero,” he said.
“Because he plays tomorrow. My goalkeeper is always the best goalkeeper in the world. Now David is third best. Romero is number one and Joel number two . David is third best.”